Website The University of British Columbia
A PhD graduate student position is available in the lab of Dr. Kelly Brown in the Department of Microbiology and Immunology at the University of British Columbia in Vancouver, Canada. The graduate student will join a multidisciplinary team of scientists and clinical investigators working towards the improved understanding of immunological mechanisms of childhood rheumatic diseases in order to aid diagnosis and therapeutic decision making for affected children.
- These biomarkers and improved mechanistic understanding of vasculitis are desperately needed to help doctors classify and assess the disease at onset and over disease course. The ability to do this has many downstream benefits including enabling access to the right therapy, in the right dose and at the right time – thereby minimizing damaging effects afflicted by both the disease and the drug – and by helping individuals and their families plan for the future.
- We are seeking a highly motivated PhD candidate to participate in the discovery and validation of novel biomarkers and driving mechanisms behind childhood-onset vasculitis. Vasculitis is a rheumatic disease that affects children and adults and develops when blood vessels carrying oxygen to critical organs in the body (inclusive of the brain, kidneys and lungs) are damaged by inflammation.
- The student’s project will build from a solid foundation of published and preliminary data that was amassed with prior support from the Canadian Institutes of Health Research. Specifically, the student will work towards the i) validation and prospective testing of biomarkers for diagnosis and assessment of overall and organ-specific disease activity, and ii) unravel the contribution of innate and adaptive processes to disease onset, severity, and response to treatment.
- The rheumatic disease family is a collection of multiple diseases that include the more commonly known juvenile arthritis (JA), rarer conditions like vasculitis and systemic lupus erythematosus (SLE), and the more recently characterised autoinflammatory diseases. Despite genetic and phenotypic differences, all rheumatic diseases are characterized by relapsing and remitting episodes of inflammation.
- At the time of the application or by the award start date, the applicant must:
- Preference will be given to Canadian applicants
- Have completed a BSc or MSc in a relevant field of study (e.g., immunology, biochemistry, medical genetics) with strong academic performance;
- Strong interpersonal and communication skills, demonstrated resilience, and the ability to work in a team environment;
- Experience in immunological techniques (including flow cytometry, ELISA and qPCR) as evidenced by a strong publication record would be an asset
Company: The University of British Columbia
Vacancy Type: Full Time
Job Location: Vancouver, BC, USA
Application Deadline: N/A